Dosimetry and Therapeutic Ratios for Rhenium-186 HEDP
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چکیده
منابع مشابه
Pharmacokinetics of rhenium-186 after administration of rhenium-186-HEDP to patients with bone metastases.
The pharmacokinetics of 186Re-HEDP, a radiopharmaceutical for palliative treatment of metastatic bone pain, was investigated in 11 patients (17 studies) who suffered from metastatic breast or prostate cancer. Half-life times of 186Re in three blood fractions (whole blood, plasma and plasma water) were 40.1 +/- 5.0, 41.0 +/- 6.0 and 29.5 +/- 6.4 hr, respectively. Time-dependent increase in plasm...
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Rhenium-186 (tin)-labeled hydroxyethylidene diphosphonate (186Re-labeled HEDP) was evaluated in 27 men with progressive androgen-independent prostate cancer and bone metastases. Administered activities ranged from 1251 to 4336 MBq (33.8-117.2 mCi). The primary objectives were to assess tumor targeting, normal organ dosimetry, and safety. Antitumor effects were assessed by posttherapy changes in...
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With the recent interest on the theranostic approach, there has been a renewed interest for alternative radionuclides in nuclear medicine. They can be produced using common production routes, i.e., using protons accelerated by biomedical cyclotrons or neutrons produced in research reactors. However, in some cases, it can be more valuable to use deuterons as projectiles. In the case of Cu-64, sm...
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UNLABELLED The clinical picture of bone metastases is manifested by pain and loss of mechanical stability. Standard treatment options for bone metastases include external beam radiotherapy and the use of analgesics. Due to a large number of lesions in many patients, the use of radionuclide therapy with beta emitters may be preferable. Re-186 hydroxyethylidene diphosphonate (Re-186 HEDP) is one ...
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The twoand three-dimensional ~2D and 3D! versions of ALEGRA-HEDP @A. C. Robinson and C. J. Garasi, ‘‘Three-dimensional Z-pinch wire array modeling,’’ Computer Physics Communications, submitted# have been utilized to simulate discrete wire effects including precursor formation in 2D (r-u plane! and nonuniform axial ablation ~3D!. Comparisons made between 2D and 3D simulations indicate that 2D si...
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ژورنال
عنوان ژورنال: ISRN Molecular Imaging
سال: 2013
ISSN: 2090-8962
DOI: 10.1155/2013/124603